主要应用
The main application
Liposome doxorubicin
Amphotericin B liposome
Paclitaxel liposomes
Oxaliplatin liposomes
Irinotecan liposome
SiRNA liposome
Albumin paclitaxel nanoparticles
Nucleic acid liposome
Other whole li posome samples
挤出原理
Technical features
脂质体挤出的原理在于，通过一定的挤出动力源将脂质体样品粒子进行挤压，使其在一定压力条件下通过 PC滤膜， 此压力作为粒子过膜过程中的剪切力可使其达到粒径控制的效果。不论形态、大小和分布都可得到极大改善。
The principle of liposome extrusion is that the particles of liposome sample are extruded by a certain extrusion power source to pass through the PC membrane under a certain pressure. The pressure acts as the shear force in the process of the particles passing through the membrane, which can achieve the effect of particle size control. The shape, size and distribubtion can be greatly improved.
支撑板和滤板主要起到支撑滤膜的作用。 由于磷脂有一定的相变温度，所以在挤出之前需要对挤出器夹套通入恒温水进行预热至一定温度（50~60℃），且在使用过程中需保持在此温度。通常的脂质体品种挤出之后粒径能达到 100nm以下，PDI 能控制在 0.1 以下。
The support plate and the filter plate mainly play the role of supporting the filter membrane.Because of phospholipids have certain phase change temperature before extrusion need access to extruder jacket thermostatic water preheated to a certain temperature (50 ~ 60 ℃), and needs to keep the temperature in the process of use.The particle size of the normal liposome can reach below 100nm after extrusion, and the PDI can be controlled below 0.1.
动力源：氮气
Power source: nitrogen
技术特征
Technical features
核心部件 The core components
Support plate (SS316L stainless steel)
Filter plate (SS316L stainless steel)
Filter membrane :PC material (polycarbonate)
Sealing system: PU material/polytetrafluoroethylene
Temperature control system: jacket control warm water
技术特点 Technical characteristics
Low sample consumption
High extrusion pressure
No residue
No manual operation required
Whole process temperature control
All parts including "O" rings, gaskets are FDA approved
Easy loading and unloading, easy cleaning and sterilization
All data can be directly amplified
Can be used for high concentration sample processing
Can be used in a clean room, in line with GMP standards
技术参数
Technical Parameter
| 型号 MODEL | Extru 25-20 |
|
最高压力 [Mpa] The highest pressure[Mpa] |
25 |
|
最终产品粒径 [nm] Final product size [nm] |
50~1000 |
|
单批处理量[ml] The Final product size[ml] |
0~20 |
|
最高产品浓度[mg/ml] Maximum product concentration[mg/ml] |
200 |
|
工作温度范围 Operating temperature range |
5~80℃ |
|
产品材质 Product material |
SS316L |
|
直径[mm] The diameter of[mm] |
25 |
| 动力源类型 Power source type |
Gas |
